IGF1 LR3 is an insulin-like growth factor type 1 of prolonged action. It exhibits pronounced anabolic activity, enhancing protein synthesis in many tissues of the body, which allows it to be used to build lean muscle mass, regenerate wounds and injuries, increase bone density, rejuvenation, and it also has a neuroprotective effect.
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IGF-1 LR3 is a peptide hormone with a long polypeptide chain. Insulin-like growth factor (long in R3 IGF-1), an 83-amino acid analog of the usual IGF-1 level (IGF-1), is a highly anabolic hormone released mainly in the liver under the action of growth hormone (GH). First of all, it is used by athletes to build lean muscle mass, as well as by people who want to recover faster after wounds, injuries and other injuries (since IGF-1 enhances protein synthesis in many tissues, improving their condition and accelerating the recovery of damaged areas).
- promotes the growth of dry muscles;
- preserves muscles;
- improves athletic performance;
- increases the rate of regeneration and further muscle growth after exercise;
- increases the speed of recovery after wounds, injuries, burns and other tissue damage;
- increases muscle protein synthesis;
- reduces body fat;
- enhances protein synthesis in the whole body;
- regulates fat accumulation and directs it for energy production;
- increases the rate of metabolism;
- increases the ability to regenerate nerves;
- strengthens the ligaments.
Mechanism of action
Insulin-like growth factor I (IGF-I), also known as somatomedin C, is the dominant effector of growth hormone (GH) and structurally similar to proinsulin. That is why it is called insulin-like, at the same time, due to structural similarity, it can affect glucose metabolism as insulin.
After secretion in the brain, growth hormone stimulates the production of IGF-I in most tissues. Hepatocytes (liver cells) produce IGF-I circulating in the blood, while IGF-I synthesized in local tissues is produced by many other tissues in which it has a paracrine effect (this means that it acts in the same tissues in which it is produced). IGF-I induces proliferation, migration and differentiation of a wide variety of cell types. In addition to glucose, IGF-1 participates in the metabolism of fatty acids and proteins, changes the activity of steroid hormones, as well as the metabolism of cartilage and bones (that is why it stimulates muscle growth, increases bone density and accelerates the recovery of joints, ligaments, etc.). IGF-I binds to IGF-I R, IGF-II R and insulin receptor (as mentioned above), although its effects are mediated mainly by IGF-I R. IGF-I also has a strong affinity with IGF-I binding proteins (IGFBP) that regulate the availability and biological activity of IGF-I throughout the body.
Prolonged-acting IGF-1 LR3 is a synthetic analog of IGF-I with a mass of 9.2 kDa, which is obtained by modifying the amino acid sequence of mature human IGF-I. These modifications include replacing Arg (arginine) with Glu (glutamine) at position 3 of the mature IGF-1 sequence and adding an N-terminal elongation of thirteen amino acid residues originating from growth hormone. These changes generate a protein that is still able to bind to IGF-I and insulin receptors, but exhibits significantly lower binding affinity to IGFBP compared to conventional IGF-I. As a result, IGF-1 LR3 has an extended half-life (up to 20-30 hours) and demonstrates increased biological activity compared to IGF-I. This means that you need to enter it only 1 time a day and get all the advantages of a regular IGF-1.
The most important feature of IGF-1 is its ability to cause muscle hyperplasia in the human body (that is, an increase not in the size of muscle fibers, but in their number). The muscles of a person taking other anabolic drugs increase due to hypertrophy (that is, an increase in the size of each muscle fiber). On the other hand, IGF-1 leads to hyperplasia, which implies the growth and development of new muscle cells. In other words, the weight gain you will experience from using IGF-1 is not related to water retention. The weight gain is caused by the actual growth of dry muscles and is a long-term effect.